Light‐Responsive Elastin‐Like Peptide‐Based Targeted Nanoparticles for Enhanced Spheroid Penetration
نویسندگان
چکیده
We describe here a near infrared light-responsive elastin-like peptide (ELP)-based targeted nanoparticle (NP) that can rapidly switch its size from 120 to 25 nm upon photo-irradiation. Interestingly, the targeting function, which is crucial for effective cargo delivery, preserved after transformation. The NPs are assembled (targeted) diblock ELP micelles encapsulating photosensitizer TT1-monoblock conjugates. Methionine residues in this monoblock photo-oxidized by singlet oxygen generated TT1, turning ELPs hydrophilic and thus trigger NP dissociation. Phenylalanine diblocks then interact with TT1 via π-π stacking, inducing re-formation of smaller NPs. Due their small penetrate deeper spheroids kill cancer cells more efficiently compared larger ones. This work could contribute design “smart” nanomedicines penetration capacity anticancer therapies.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2023
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202300511